Author: Air Aesthetics & Wellness Clinics Clinical Team, led by Dr. Claire Oliver (GDC 70918)
Last updated: May 2026

Polynucleotides are one of the biggest steps forward in aesthetic medicine for a long time. Plinest and Newest™ are regenerative injectables made by Mastelli, both designed to improve skin quality from within. Polynucleotide treatment benefits answer a different question to most treatments people are used to.

• Fillers add volume. 
• Anti-wrinkle injections reduce movement. 
• Polynucleotide treatment asks what the skin actually needs to repair itself and delivers exactly that. 

At Air Aesthetics & Wellness Clinics, our doctor-led team uses Plinest, the first polynucleotide product in the UK with a clinically proven formula combining Polynucleotides-HPT™ and hyaluronic acid.

What Is Polynucleotide Treatment?

Polynucleotide treatment is a regenerative injectable that uses purified DNA fragments derived from salmon sperm or trout sperm to stimulate the skin's natural repair and renewal processes. These fragments, known as polydeoxyribonucleotides (PDRNs) or polynucleotides (PNs), are injected directly into the dermis where they reach fibroblast cells.

Fibroblasts are responsible for producing collagen and connective tissue. As we age, collagen production declines and these cells slow down. Polynucleotides reactivate them, as supported by published clinical research. The skin produces more of what it needs to look firmer, lifted, smoother and hydrated. No volume added. No structure altered.

Why Polynucleotides? Who Is This For?

Many people reach a point where fillers no longer feel right. The face looks fuller but the skin itself still looks tired, dull or crepey. Polynucleotide treatment addresses that directly. It works at the level of skin quality.

A polynucleotide treatment suits people who:

• Want natural-looking improvement without altering their features
• Have noticed their skin losing firmness, lift and radiance with age
• Are concerned about the face and neck ageing at different rates
• Have tried fillers and want something that works with their biology
• Are in their 30s, 40s, 50s or beyond and want to invest in long-term skin health

It also works well as a preventative treatment for younger skin. Starting polynucleotide treatment before significant collagen loss occurs means maintaining the skin's infrastructure from a position of strength.

Why Air Aesthetics Uses Plinest

At Air Aesthetics & Wellness Clinics, Plinest is our chosen polynucleotide product for the delicate skin around the eyes. Its unique formula combines Polynucleotides-HPT™ and hyaluronic acid. The hyaluronic acid improves hydration and skin elasticity immediately, supporting the environment in which the polynucleotides work. The Polynucleotides-HPT™ then stimulate fibroblasts to produce new collagen over time. A single-ingredient polynucleotide product cannot replicate this combined effect, which is why we select Plinest specifically for eye area treatments.

Clinical trials for Newest™ demonstrate a 67% increase in moisturising levels and a 68% increase in elasticity. These are measurable, diagnostic results recorded using standardised skin analysis, not marketing figures.

Clinical trials for Plinest show that 91% of patients demonstrated clinical improvement in the reduction of superficial fine lines and wrinkles, alongside a 14.7% improvement in skin hydration and a 21.8% increase in skin elasticity. These figures come from physician assessment and standardised skin measurement, not marketing claims.

5 Remarkable Results - Polynucleotide Treatment Benefits

Here are the top 5 polynucleotide treatment benefits:

1. Firmer, Lifted Skin

Polynucleotides stimulate fibroblasts (the holy grain of collagen regeneration) to produce new collagen, restoring the structural integrity of the dermis. Skin that has begun to sag or lose definition becomes firmer and lifted over a course of treatment. Genuine structural improvement.

2. Deep, Measurable Hydration

The Plinest formula delivers immediate hydration from hyaluronic acid and longer-term moisture retention from improved cellular function. Clinical data shows a 67% improvement in moisturising levels. Skin looks plumper, feels softer and the dull, dehydrated appearance associated with ageing reduces noticeably.

3. Smoother Texture and Reduced Fine Lines

As new collagen accumulates in the dermis, the skin surface smooths. Fine lines soften. Crepey skin on the face and neck responds well to polynucleotide therapy because the mechanism addresses the root cause: declining cellular activity.

4. Improved Skin Quality on the Neck and Décolletage

The neck ages differently from the face and is overlooked in many aesthetic treatment plans. The skin is thinner, receives less daily care and shows crepiness, horizontal lines and laxity that fillers cannot address. Polynucleotide treatment is well-suited to the neck and décolletage because it works on skin quality. Plinest can be applied across the face, neck and chest in a single treatment plan.

5. A More Rested, Radiant Appearance

Clients consistently describe the cumulative effect as looking like themselves, but healthier. The skin glows. The face looks rested. People notice without being able to identify the cause. That is the point.

Polynucleotide Treatment vs Fillers and Anti-Wrinkle Injections

Polynucleotides do not replace fillers or anti-wrinkle injections for everyone. For clients who need volume restoration or want to address deep structural changes, fillers remain an appropriate option. Polynucleotide treatment delivers what fillers cannot: genuine improvement in skin quality and health.

For many clients at Air Aesthetics & Wellness Clinics, the most effective approach combines polynucleotide treatment with other modalities. Our doctor-led team builds a plan around your skin.

What to Expect: Polynucleotide Treatment at Air Aesthetics

A polynucleotide session takes approximately 45 to 60 minutes depending on the areas treated.

1. Step 1. Dr. Claire Oliver (GDC 70918) or a member of our clinical team assesses your skin, discusses your goals and confirms suitability for Newest™.
2. Step 2. The skin is cleansed and a topical numbing cream is applied.
3. Step 3. Newest™ is injected using fine needles into the dermis across the treatment areas. The face and neck can be treated in the same session.
4. Step 4. Post-treatment care is applied and aftercare guidance is provided before you leave.

Side effects are minimal. Mild redness, swelling or light bruising at injection sites can occur and resolve within 24 to 48 hours. There is no significant downtime.

How Many Polynucleotides Treatments Do You Need?

Polynucleotides treatment results build progressively. The skin's collagen response takes time to develop, which is why a course produces better outcomes than a single session.

Who Is Polynucleotide Treatment Suitable For?

Polynucleotide treatment suits most adults who want to improve skin quality. It addresses a wide range of concerns:

• Fine lines and wrinkles
• Loss of firmness and lift on the face and neck
• Crepey or thinning skin
• Dullness and dehydration
• Uneven skin tone and texture
• Skin recovery after sun damage
• Preventative treatment for those in their 30s wanting to maintain collagen levels

Who Should Not Have Polynucleotide Treatments?

• Those with a confirmed fish or seafood allergy
• Anyone following a vegan or vegetarian lifestyle (Newest™ is derived from fish DNA)
• Pregnant or breastfeeding women
• Those with active skin infections or inflammatory conditions in a current flare
• Those with autoimmune conditions (consultation required)

A full clinical consultation with our team will confirm your suitability and identify the right treatment approach for your skin.

Polynucleotide Treatment FAQs

Book Your Polynucleotide Treatment at Air Aesthetics & Wellness Clinics

Air Aesthetics & Wellness Clinics is a multi-award winning group of medical-grade aesthetics clinics. Our doctor-led team, under the clinical leadership of Dr. Claire Oliver (GDC 70918), uses only the highest quality products and medical-grade devices to deliver results that are safe and lasting.

Newest™ is available at our clinics in Henley-in-Arden, Leamington Spa, Birmingham and St Albans.

Book your complimentary consultation and take the first step towards skin that repairs, renews and glows.

You can also learn more about Air Aesthetics & Wellness Clinics and our full range of treatments.

All treatments at Air Aesthetics & Wellness Clinics are performed by trained aesthetic professionals following a full clinical consultation. This article is for informational purposes only and does not constitute medical advice.